Welcome to the Top 12 Running Back Plays for Week 6! This week we have injuries and bye weeks to navigate through to set our lineups. The Falcons, Jets, 49ers, and Saints are taking the week off. While Dalvin Cook and Chris Carson are questionable to play, Saquon Barkley is doubtful, and Clyde Edwards Helaire was moved to the IR.

Some of the players I have for the top running back plays are listed as questionable, so you might need to double-check your lineup before game time to make sure they are not going to be inactive. Who all do I have listed? Let’s take a look!

Top 12 Running Back Plays for Week 6

Jonathan Taylor, IND vs HOU

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Jonathan Taylor is coming off of a good game against the Baltimore Ravens on Monday night where he rushed for 53 yards and caught 3 passes for 116 yards and 2 total touchdowns. Most of the receiving yards came off of a 76-yard touchdown reception. The Colts will host the Texans in a Week 6 matchup. The Texans gave up 674 yards (7th most) and 9 scores (tied for most) rushing. Taylor has 327 yards and 2 scores rushing for the 2021 season.

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Antonio Gibson, WAS vs KC

Antonio Gibson is one of the running backs that is questionable heading into Week 6. He will be facing off against the Kansas City Chiefs in Washington on Sunday. Kansas City has allowed the 4th most rushing yards with 705 and is tied for the most rushing touchdowns with 9. Gibson has 313 yards rushing and 3 scores throughout the season.

Nick Chubb, CLE vs ARI

Nick Chubb hasn’t rushed for less than 83 yards in a game yet this season, including rushing for over 100 yards the last 2 weeks against the Vikings and Chargers. The Browns will host the Cardinals on Sunday. The Cardinals have allowed the 5th most rushing yards with 695 and 3 rushing touchdowns, which is tied for the 5th fewest. Nick Chubb has 523 yards and 4 touchdowns rushing.

Joe Mixon, CIN at DET

Joe Mixon was questionable headed in the Bengals game against the Packers and played limited snaps. He finished with 33 rushing yards and a score. The Bengals will head to Detroit on Sunday. The Lions have given up the 10th most rushing yards with 651 and are tied with the 7th most touchdowns given up on the ground with 6. Through 5 weeks, Mixon has 386 yards and 3 scores.

James Robinson, JAX vs MIA (London)

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James Robinson is coming off a 149-yard rushing and one-score game against the Titans. The Jaguars will host the Miami Dolphins on Sunday in London. The Dolphins have given up the 9th most rushing yards to opponents this season with 668 and are tied for 7th most touchdowns surrendered with 6. Robinson has rushed for 387 rushing yards and 4 scores through the first 5 weeks of the season.

Najee Harris, PIT vs SEA (SNF)

Najee Harris had his first 100-yard rushing game against the Broncos in Week 5. For the season, Harris has 307 yards and 3 scores rushing He also has 28 receptions for 198 yards and a score. The Steelers will host the Seahawks on Sunday Night Football. Seattle’s defense has given up 726 rushing yards, which is 2nd most, and are tied at 12th most for touchdowns scored with 5.

Christian McCaffrey, CAR vs MIN

It looks like Christian McCaffrey could be a game-time decision on Sunday. He was hurt during the Panthers game against the Texans in Week 3 and hasn’t played since. Through those 3 games, McCaffrey has 201 yards and 1 touchdown rushing to go with 16 receptions for 163 yards receiving. The Vikings have given up the 11th most rushing yards with 650 and are tied for the 12th most rushing touchdowns with 5.

Melvin Gordon, DEN vs LV

Melvin Gordon hasn’t produced quite like a lot on this list. He splits time with Javonte Williams and isn’t targeted a lot in the passing game. Coming into his Week 6 matchup versus the Raiders, Gordon has just 282 yards rushing and 2 scores. However, the Las Vegas defense gives up the 5th most rushing yards with 672 and 7 touchdowns on the ground–tied for the 4th most in the NFL.

Derrick Henry, TEN vs BUF (MNF)

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Derrick Henry leads the NFL in rushing attempts with 142, rushing yards with 640, and rushing touchdowns with 7. He has had 4 straight games of 113 rushing yards or more. Henry and the Titans will be visiting the Buffalo Bills on Monday Night Football. The Bills have been extremely good against running backs this season. They have only given up 392 yards rushing, which is good for 3rd fewest, and only 1 touchdown which is tied for best in the NFL.

D’Andre Swift, DET vs CIN

D’Andre Swift doesn’t have a game where he has rushed for over 55 yards yet this season. For the season, he has 190 yards rushing and 2 scores. He also has 29 receptions for 252 yards and a score through the air. The Lions will host the Bengals for a Week 6 matchup on Sunday. The Bengals have given up 507 yards rushing, good for the 10th fewest, and 4 touchdowns, which is also good for the 10th fewest in the NFL.

Leonard Fournette, TB at PHI (TNF)

Leonard Fournette’s numbers won’t “Wow” you for this season. He has 251 yards and 1 score on the ground, he also added 19 catches for 197 yards. The Tampa Bay Buccaneers like to throw the ball, but the Eagles’ defense has given up a decent amount of rushing yards. They have surrendered 710 rushing yards, good for the 3rd most, but only 4 touchdowns, the 10th fewest in the NFL.

Myles Gaskin, MIA at JAX (London)

Myles Gaskin and the Dolphins will travel to London to play the Jacksonville Jaguars on Sunday. Gaskin has 167 rushing yards and 22 receptions for 131 yards with 2 scores through the first 5 games of the season. The Jacksonville Jaguars have allowed the 13th most rushing yards with 609 and are tied for the most touchdowns given up on the ground with 9. Gaskin is coming off a game where he caught 10 passes for 74 yards and 2 scores against the Bucs.

That wraps up the Top 12 Running Back Plays for Week 6. As always thank you for stopping by. Remember, to check out articles like this and more, go to RotoHeat.com and join the conversation in our Facebook group.

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